What Challenges Exist in Targeting Base Modifications for Cancer Therapy?
Several challenges remain in targeting base modifications for cancer therapy:
1. Specificity: Ensuring that drugs specifically target cancer cells without affecting normal cells is critical to minimizing side effects.
2. Resistance: Cancer cells can develop resistance to epigenetic drugs, necessitating combination therapies and novel approaches.
3. Complexity: The interplay between different base modifications and the broader epigenetic landscape is highly complex, making it difficult to predict the outcome of targeting a single modification.
