Chromatin Immunoprecipitation (ChIP) is an experimental technique used to investigate the interaction between proteins and DNA in the cell. This method allows researchers to determine the specific locations on the genome where particular proteins, such as transcription factors or histone modifications, bind. The procedure involves cross-linking proteins to DNA, shearing the DNA into smaller fragments, immunoprecipitating the protein-DNA complexes using specific antibodies, and then identifying the DNA sequences bound by the protein.
