What is the Role of Phospholipids in Cell Signaling?
Phospholipids are involved in various cell signaling mechanisms. For instance, phosphatidylinositol 4,5-bisphosphate (PIP2) can be hydrolyzed to produce inositol trisphosphate (IP3) and diacylglycerol (DAG), both of which are secondary messengers in signaling pathways that regulate cell proliferation, survival, and migration. The dysregulation of these pathways is a hallmark of cancer, making phospholipids crucial players in the disease's progression.
