What is the Role of VEGFR-3 in Angiogenesis and Lymphangiogenesis?
While VEGFR-2 is more commonly associated with angiogenesis (formation of blood vessels), VEGFR-3 is primarily involved in lymphangiogenesis. However, recent studies indicate that VEGFR-3 can also influence angiogenesis in certain contexts. In cancer, the receptor helps in the development of new lymphatic vessels, facilitating the spread of cancer cells to lymph nodes and beyond.