What Mechanisms Lead to SMAD7 Dysregulation in Cancer?
Several mechanisms can lead to the dysregulation of SMAD7 in cancer, including genetic mutations, epigenetic modifications, and post-translational modifications. For example, promoter hypermethylation can silence SMAD7 expression, while mutations in the SMAD7 gene can lead to loss of function. Additionally, ubiquitination and subsequent proteasomal degradation can decrease SMAD7 protein levels.
