What Types of Cancer are Associated with SMAD7 Dysregulation?
SMAD7 dysregulation has been observed in various types of cancer, including colorectal cancer, gastric cancer, and pancreatic cancer. In colorectal cancer, for example, SMAD7 overexpression is commonly associated with poor prognosis due to its role in blocking TGF-β's tumor-suppressive effects. In contrast, some studies suggest that SMAD7 downregulation in gastric cancer can contribute to tumor progression.
