What Role Does Desmoplasia Play in Cancer Progression?
Desmoplasia plays a dual role in cancer progression. On one hand, the fibrotic tissue can act as a physical barrier that impedes the delivery of chemotherapeutic agents and immune cells to the tumor, making the cancer more resistant to treatment. On the other hand, the rigid ECM can also promote cancer cell invasion and metastasis by providing structural support and biochemical signals that facilitate tumor cell movement.
