Several cancer treatments are known for their nephrotoxic effects:
- Cisplatin and Carboplatin: These platinum-based chemotherapeutic agents are notorious for causing acute kidney injury. - Methotrexate: High doses of methotrexate can lead to renal toxicity by forming insoluble complexes that precipitate in the renal tubules. - Ifosfamide: This alkylating agent can cause hemorrhagic cystitis and proximal tubular dysfunction. - Immunotherapy: Some immune checkpoint inhibitors can lead to autoimmune kidney injury. - Targeted Therapies: Certain targeted therapies, such as tyrosine kinase inhibitors, can induce proteinuria and kidney damage.
