Cancers can develop mechanisms to evade immune detection, a phenomenon known as immune evasion. Some tumors may downregulate the expression of major histocompatibility complex (MHC) molecules, making it harder for T cells to recognize them. Others may secrete immunosuppressive factors or recruit regulatory T cells (Tregs) to inhibit the immune response. Additionally, mutations may arise that help cancer cells mimic normal cells, further evading immune detection.