Choline kinase (ChoK) is an enzyme that catalyzes the phosphorylation of choline to phosphocholine. This reaction is a critical step in the biosynthesis of phosphatidylcholine, a major component of cell membranes. The enzyme exists in multiple isoforms, with ChoKα and ChoKβ being the most studied. Increased activity of ChoK, particularly the α isoform, has been associated with various types of cancer, making it a potential target for cancer therapy.
