Why Does Immune Rejection Fail in Cancer Patients?
Cancer cells employ various mechanisms to evade immune detection. Some of these include:
Downregulation of MHC molecules, making it harder for T cells to recognize them. Secretion of immunosuppressive molecules like TGF-beta and IL-10. Creation of a tumor microenvironment that is hostile to immune cells. Expression of immune checkpoint molecules such as PD-L1, which inhibit T cell activity.
