How are ribosomes and protein synthesis affected in cancer?
Cancer cells typically exhibit increased rates of protein synthesis to support their rapid growth and division. This is often achieved through the overactivation of ribosomal biogenesis and the mTOR signaling pathway, which regulates protein synthesis. Some cancers also display mutations in ribosomal proteins or factors involved in the translation process, further driving tumorigenesis. Targeting these pathways is a potential therapeutic strategy.
