How Can T Cell Activation Be Enhanced for Cancer Therapy?
There are several strategies to enhance T cell activation in cancer therapy:
Immune checkpoint inhibitors: These are drugs that block the inhibitory signals from immune checkpoints like PD-1/PD-L1 and CTLA-4, thereby enhancing T cell activation. CAR T-cell therapy: This involves engineering a patient's own T cells to express chimeric antigen receptors (CARs) that specifically target cancer cells. Cancer vaccines: These vaccines aim to stimulate the immune system by presenting tumor-specific antigens, thus enhancing T cell activation against cancer cells. Adoptive T cell transfer: This involves isolating T cells from a patient or donor, expanding them in vitro, and then reintroducing them into the patient to fight cancer.
