How Does Cremophor EL Affect Drug Pharmacokinetics?
Cremophor EL can impact the pharmacokinetics of the drugs it solubilizes. It can alter drug distribution, metabolism, and excretion. For instance, Cremophor EL has been shown to impact the distribution of paclitaxel by enhancing its penetration into tissues. This can be beneficial but also complicates the pharmacokinetic profile, necessitating careful monitoring and dose adjustments.
