Lymphoma spreads through the lymphatic system, which includes lymph nodes, spleen, thymus, and bone marrow. In some cases, it can also spread to other organs outside the lymphatic system. The spread, or metastasis, occurs when cancerous lymphocytes travel through the lymphatic vessels and form new tumors in other parts of the body. The mechanism of spread can vary depending on whether it is Hodgkin or Non-Hodgkin Lymphoma.