Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is a genetic condition that significantly increases the risk of developing colorectal and other cancers. It is caused by inherited mutations in MMR genes such as MLH1, MSH2, MSH6, and PMS2. Individuals with Lynch syndrome often exhibit MSI-H in their tumors, which can help in the diagnosis and management of the syndrome.
