PDGFR has been extensively studied in the context of cancer due to its role in regulating cell proliferation and survival. Abnormal activation of PDGFR through mutations, amplifications, or autocrine loops can lead to uncontrolled cell growth, a hallmark of cancer. This aberrant signaling is implicated in various malignancies including glioblastoma, sarcomas, and chronic myelomonocytic leukemia.
