What Types of Cancers are Associated with PDGFR Abnormalities?
PDGFR abnormalities are linked to several types of cancer. In glioblastoma, PDGFR-alpha is often overexpressed or mutated, contributing to tumor growth and resistance to therapy. In sarcomas, particularly gastrointestinal stromal tumors (GISTs), mutations in PDGFR-alpha are a common driver of oncogenesis. PDGFR-beta is implicated in certain leukemias, such as chronic myelomonocytic leukemia, where it can form fusion proteins with other genes, leading to constitutive activation of the receptor.
