What are the Downstream Signaling Pathways of PDGFR?
Upon activation, PDGFR initiates several downstream signaling pathways that mediate its cellular effects. Key pathways include the PI3K-AKT pathway, which promotes cell survival and growth; the RAS-MAPK pathway, which drives cell proliferation; and the PLCγ pathway, which is involved in cell motility. Dysregulation of these pathways due to continuous PDGFR activation can lead to oncogenesis.
