PDGFR activation is tightly regulated under normal conditions. Binding of its ligands, PDGF (Platelet-Derived Growth Factor) isoforms, induces dimerization and autophosphorylation of the receptor, initiating downstream signaling pathways. This activation is normally balanced by mechanisms such as receptor internalization and degradation, as well as the presence of natural antagonists like tyrosine phosphatases that dephosphorylate the receptor.
