What are Proteolysis Targeting Chimeras (PROTACs)?
Proteolysis Targeting Chimeras, commonly known as PROTACs, are a novel class of small molecules designed to induce the targeted degradation of specific proteins. They work by hijacking the cell's natural protein degradation machinery, particularly the ubiquitin-proteasome system (UPS), to selectively eliminate disease-causing proteins. This is achieved by linking a target protein to an E3 ubiquitin ligase, leading to its ubiquitination and subsequent degradation by the proteasome.
