What is the significance of PROTACs in Cancer treatment?
The development of PROTACs represents a significant advancement in targeted cancer therapy. Traditional small molecule inhibitors often face challenges such as drug resistance and limited efficacy due to the presence of undruggable targets. PROTACs offer a solution by degrading, rather than merely inhibiting, the target proteins. This approach has the potential to overcome resistance mechanisms and provide a more sustained therapeutic effect. Moreover, PROTACs can target proteins that are considered "undruggable" by conventional therapies, broadening the scope of treatable cancers.
