What are the main advantages of PROTACs over traditional cancer therapies?
One of the primary advantages of PROTACs is their ability to address drug resistance. By degrading the target protein, PROTACs eliminate the protein's function entirely, reducing the likelihood of resistance mechanisms that often arise with inhibitors. Additionally, PROTACs have a catalytic mode of action, meaning they can be reused to degrade multiple copies of the target protein, potentially leading to lower required doses and reduced side effects. PROTACs also offer the ability to target a wider range of proteins, including those previously deemed undruggable.
