What are the challenges associated with PROTAC development?
Despite their promising potential, several challenges remain in the development of PROTACs. One major challenge is the requirement for the PROTAC molecule to effectively engage both the target protein and the E3 ligase simultaneously, which can be difficult to achieve with high specificity and affinity. The design of the linker that connects the two ligands is also critical and can significantly impact the efficacy and selectivity of the PROTAC. Additionally, off-target effects and the potential for immune responses are concerns that need to be addressed through careful optimization and testing.
