What are the current strategies to inhibit MDSC recruitment?
Several strategies are being explored to inhibit MDSC recruitment, including:
1. Targeting Chemokine Pathways: Blocking chemokine receptors such as CCR2 and CXCR4 can prevent MDSCs from migrating to the tumor site. Agents like CCR2 inhibitors and CXCR4 antagonists are being studied for this purpose.
2. Inhibiting Growth Factors: Targeting growth factors like VEGF and GM-CSF that promote MDSC recruitment and expansion. Anti-VEGF therapies, for example, have shown potential in reducing MDSC levels.
3. Blocking Immunosuppressive Signals: Using agents that interfere with immunosuppressive signals, such as arginase inhibitors, can reduce the suppressive function of MDSCs.
4. Combining Therapies: Combining MDSC-targeting agents with other treatments like immune checkpoint inhibitors or chemotherapy to achieve a synergistic effect.
