What Are the Limitations and Challenges of Cryo-EM?
Despite its advantages, Cryo-EM has some limitations:
1. Sample Preparation: The process of preparing samples for Cryo-EM can be technically challenging and time-consuming. 2. Cost and Accessibility: High-end Cryo-EM equipment is expensive, and access to such instruments is limited to well-funded research institutions. 3. Data Interpretation: The interpretation of Cryo-EM data requires sophisticated software and expertise in computational biology.
