CNAs have significant clinical implications. They can:
Serve as biomarkers for cancer diagnosis and prognosis. For example, the presence of specific CNAs can indicate a more aggressive cancer or predict the likelihood of recurrence. Inform treatment decisions. Targeted therapies can be developed to specifically address the genetic alterations caused by CNAs. For instance, HER2-targeted therapies are effective in patients with HER2-amplified breast cancer. Help monitor disease progression and response to treatment. Changes in CNAs over time can provide insights into how a tumor is evolving and responding to therapy.