somatic copy number alterations (cnas)

What is the Clinical Significance of CNAs?

CNAs have significant clinical implications. They can:
Serve as biomarkers for cancer diagnosis and prognosis. For example, the presence of specific CNAs can indicate a more aggressive cancer or predict the likelihood of recurrence.
Inform treatment decisions. Targeted therapies can be developed to specifically address the genetic alterations caused by CNAs. For instance, HER2-targeted therapies are effective in patients with HER2-amplified breast cancer.
Help monitor disease progression and response to treatment. Changes in CNAs over time can provide insights into how a tumor is evolving and responding to therapy.

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